Development of Malignant Melanoma of the Orbit in Previous Radiation Field

We present a case of a 40-year-old woman with a history of retinoblastoma in the left eye treated with enucleation and radiation therapy as an infant who recently developed worsening pain and exophthalmos in her right eye. Multimodality imaging demonstrated an enhancing, FDG-avid mass in the medial...

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Bibliographic Details
Published inClinical nuclear medicine Vol. 40; no. 11; p. e522
Main Authors Ahmed, Shamima, McDonald, Nicholas, Lowder, Lindsey, Mahoney, Bruce
Format Journal Article
LanguageEnglish
Published United States 01.11.2015
Subjects
Adult
Female
Fluorodeoxyglucose F18
Humans
Melanoma - diagnostic imaging
Melanoma - pathology
Neoplasms, Radiation-Induced - diagnostic imaging
Neoplasms, Radiation-Induced - pathology
Orbital Neoplasms - diagnostic imaging
Orbital Neoplasms - pathology
Positron-Emission Tomography
Radiopharmaceuticals
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Summary:We present a case of a 40-year-old woman with a history of retinoblastoma in the left eye treated with enucleation and radiation therapy as an infant who recently developed worsening pain and exophthalmos in her right eye. Multimodality imaging demonstrated an enhancing, FDG-avid mass in the medial right orbit with associated bone destruction and extension into the ethmoid sinus. Pathologic analysis after excision showed a highly undifferentiated tumor consistent with melanoma. Although development of malignant melanoma in an irradiated field is rare, it should be considered in the differential, especially in childhood cancer survivors at increased risk of second malignant neoplasms.
ISSN:1536-0229
DOI:10.1097/RLU.0000000000000865