Impact of interaction between interleukin-6 gene polymorphism and Helicobacter pylori infection on susceptibility to gastric cancer

• Published in: European journal of cancer prevention Vol. 33; no. 2; p. 136
• Main Authors: Wang, Longyue, Xiao, Shuaishuai, Zheng, Yiming, Gao, Zefeng, Fan, Fan
• Format: Journal Article
• Language: English
• Published: England 01.03.2024
• Subjects: Case-Control Studies; Genetic Predisposition to Disease; Genotype; Helicobacter Infections - complications; Helicobacter Infections - diagnosis; Helicobacter Infections - genetics; Helicobacter pylori; Humans; Interleukin-6 - genetics; Polymorphism, Single Nucleotide - genetics; Stomach Neoplasms - epidemiology; Stomach Neoplasms - genetics
• ISSN: 1473-5709
• DOI: 10.1097/CEJ.0000000000000835

This study aimed to evaluate the association between four single nucleotide polymorphisms (SNPs) of the interleukin-6 (IL-6) gene and gastric cancer (GC), and impact of interaction between IL-6 SNPs and Helicobacter pylori (H. pylori ) infection on susceptibility to GC. Logistic regression was used to test the relationships between four SNPs of IL-6 gene and GC susceptibility. A generalized multifactor dimensionality reduction (GMDR) model was employed to assess the interaction effect between IL-6 gene and H. pylori infection on GC risk. Logistic regression analysis indicated that the rs1800795-C allele was associated with increased GC risk, adjusted ORs (95% CI) were 1.80 (1.21-2.41) (CC vs. GG) and 1.68 (1.09-2.30) (C vs. G), respectively. The rs10499563-C allele was associated with decreased risk of GC, and adjusted ORs (95% CI) were 0.62 (0.31-0.93) (TC vs. TT), 0.52 (0.18-0.89) (CC vs. TT) and 0.60 (0.29-0.92) (C vs. T), respectively. GMDR methods found a two-dimensional model combination (including rs1800795 and H. pylori infection) was statistically significant. The selected model had testing balanced accuracy of 59.85% and the best cross-validation consistencies of 10/10 ( P  = 0.0107). Compared with H. pylori -negative subjects with rs1800795- GG genotype, H. pylori -positive participants with GC or CC genotype had the highest risk of GC, the OR (95% CI) was 3.34 (1.78-4.97). The rs1800795-C allele was associated with increased GC risk and the rs10499563-C allele was associated with decreased GC risk. The interaction between rs1800795 and H. pylori infection was also correlated with increased risk of GC.