Long-term Results of Matrix-assisted Autologous Chondrocyte Transplantation Combined With Autologous Bone Grafting for the Treatment of Juvenile Osteochondritis Dissecans

• Published in: Journal of pediatric orthopaedics Vol. 40; no. 2; p. e115
• Main Authors: Roffi, Alice, Andriolo, Luca, Di Martino, Alessandro, Balboni, Federica, Papio, Tiziana, Zaffagnini, Stefano, Filardo, Giuseppe
• Format: Journal Article
• Language: English
• Published: United States 01.02.2020
• Subjects: Adolescent; Bone Transplantation; Cartilage, Articular - cytology; Chondrocytes - transplantation; Female; Follow-Up Studies; Humans; Knee Joint - physiopathology; Knee Joint - surgery; Lysholm Knee Score; Male; Osteochondritis Dissecans - surgery; Quality of Life; Sex Factors; Time Factors; Transplantation, Autologous - methods; Treatment Failure
• ISSN: 1539-2570
• DOI: 10.1097/BPO.0000000000001404

Osteochondritis dissecans is a pathology affecting young patients that involves the entire osteochondral unit. In the case of unfixable fragments, regenerative cartilage treatments are a viable solution, but little is known about the use of these procedures for the treatment of juvenile osteochondritis dissecans (JOCD). The aim of this study was to evaluate the long-term results offered by matrix-assisted autologous chondrocyte transplantation combined with autologous bone grafting for the treatment of JOCD. Nineteen patients have been enrolled. The mean age at the time of treatment was 16.8±1.5 years, with a mean body mass index of 22.9±2.7. The average size of the defects was 2.8±1.2 cm. All patients were evaluated prospectively before surgery and at 12, 24, 60, and at a final follow-up of 120 months with International Knee Documentation Committee scores, EuroQol-Visual Analogue Scale, and the Tegner Score. A statistically significant improvement in all clinical scores was observed from baseline evaluation to 120 months of final follow-up. In particular, the International Knee Documentation Committee subjective score improved from the preoperative evaluation of 38.7±17.3 to 74.0±21.8 at 12 months (P<0.0005), with scores remaining stable for up to 120 months (83.8±20.7), with all follow-ups showing a statistically significant improvement compared with the basal value (P<0.0005). Three patients failed at 12 months, for a failure rate of 16% at 10 years of follow-up. Lesions >3.5 cm obtained worse subjective results. In addition, lesion size and female sex were significantly associated with failures. The matrix-assisted autologous chondrocyte transplantation technique with autologous bone grafting is a valid treatment option for JOCD in case of unfixable fragments. The clinical improvement obtained is significant and stable, with good results maintained for up to 10 years of follow-up and an overall low failure rate. Lesion size and sex could influence the clinical outcome and should be considered in the treatment choice. Level IV-case series.