Pentosan Polysulfate–Associated Macular Disease in Patients With Interstitial Cystitis

• Published in: Obstetrics and gynecology (New York. 1953) Vol. 135; no. 5; pp. 1091 - 1094
• Main Authors: Lyons, Riley J, Ahmad, Samera, Ansari, Sana, Foote, Jenelle E, Jain, Nieraj
• Format: Journal Article
• Language: English
• Published: United States by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved 01.05.2020
• Subjects: Adult; Aged; Cystitis, Interstitial - drug therapy; Female; Humans; Macular Degeneration - chemically induced; Middle Aged; Pentosan Sulfuric Polyester - adverse effects

Recent studies have implicated long-term pentosan polysulfate use with vision loss from a newly described macular condition. Affected patients report difficulty with reading and adjusting to dim lighting, and they occasionally develop severe visual disability. Macular changes resemble those seen in...