Pentosan Polysulfate–Associated Macular Disease in Patients With Interstitial Cystitis

Recent studies have implicated long-term pentosan polysulfate use with vision loss from a newly described macular condition. Affected patients report difficulty with reading and adjusting to dim lighting, and they occasionally develop severe visual disability. Macular changes resemble those seen in...

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Published inObstetrics and gynecology (New York. 1953) Vol. 135; no. 5; pp. 1091 - 1094
Main Authors Lyons, Riley J, Ahmad, Samera, Ansari, Sana, Foote, Jenelle E, Jain, Nieraj
Format Journal Article
LanguageEnglish
Published United States by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved 01.05.2020
Subjects
Adult
Aged
Cystitis, Interstitial - drug therapy
Female
Humans
Macular Degeneration - chemically induced
Middle Aged
Pentosan Sulfuric Polyester - adverse effects
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Summary:Recent studies have implicated long-term pentosan polysulfate use with vision loss from a newly described macular condition. Affected patients report difficulty with reading and adjusting to dim lighting, and they occasionally develop severe visual disability. Macular changes resemble those seen in age-related macular degeneration, potentially leading to misdiagnosis. The objectives of this Current Commentary are to summarize studies evaluating the association between pentosan polysulfate use and macular disease, to educate pentosan polysulfate prescribers about the clinical manifestations of this condition, and to provide recommendations for screening at-risk patients.
ISSN:0029-7844
1873-233X
DOI:10.1097/AOG.0000000000003794