Anatomy, biochemistry, and physiology of articular cartilage

Articular cartilage serves as a load-bearing elastic material that is responsible for the frictionless movement of the surfaces of articulating joints. Its ability to undergo reversible deformation depends on its structural organization, including the specific arrangement of the matrix macromolecule...

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Bibliographic Details
Published inInvestigative radiology Vol. 35; no. 10; p. 573
Main Authors Huber, M, Trattnig, S, Lintner, F
Format Journal Article
LanguageEnglish
Published United States 01.10.2000
Subjects
Aging - pathology
Aging - physiology
Biomechanical Phenomena
Cartilage, Articular - anatomy & histology
Cartilage, Articular - metabolism
Cartilage, Articular - physiology
Chondrocytes - cytology
Chondrocytes - metabolism
Extracellular Matrix - metabolism
Extracellular Matrix - ultrastructure
Humans
Osteoarthritis - pathology
Osteoarthritis - physiopathology
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Summary:Articular cartilage serves as a load-bearing elastic material that is responsible for the frictionless movement of the surfaces of articulating joints. Its ability to undergo reversible deformation depends on its structural organization, including the specific arrangement of the matrix macromolecules and the chondrocytes. Interactions between the matrix and chondrocytes are responsible for the biological and mechanical properties of articular cartilage and enable it to respond by effecting a balance between anabolism and catabolism as well as continual internal remodeling. Age-related changes in the function of chondrocytes may contribute to the initiation and progression of osteoarthritis.
ISSN:0020-9996
DOI:10.1097/00004424-200010000-00003