The indigenous populations as the model by nature to understand human genomic-phenomics interactions

Background: The advancement of genomics has progressed in lightning speed over the past two decades. Numerous large-scale genome sequencing initiatives were announced, along with the rise of the holistic precision medicine approach. However, the field of genomic medicine has now come to a bottleneck...

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Bibliographic Details
Published inQuantitative biology Vol. 10; no. 1; pp. 35 - 43
Main Authors Hoh, Boon-Peng, Rahman, Thuhairah Abdul
Format Journal Article
LanguageEnglish
Published Beijing Higher Education Press 01.03.2022
John Wiley & Sons, Inc
Subjects
Genomics
indigenous populations
Orang Asli
phenomics
Precision medicine
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Summary:Background: The advancement of genomics has progressed in lightning speed over the past two decades. Numerous large-scale genome sequencing initiatives were announced, along with the rise of the holistic precision medicine approach. However, the field of genomic medicine has now come to a bottleneck since genomic-phenomic interactions are not fully comprehended due to the complexity of the human systems biology and environmental influence, hence the emergence of human phenomics. Results: This review attempts to provide an overview of the potential advantages of investigating the human phenomics of indigenous populations and the challenges ahead. Conclusion: We believe that the indigenous populations serve as an ideal model to excavate our understanding of genomic-environmental-phenomics interactions.
Bibliography:indigenous populations
Orang Asli
Document received on :2020-10-07
Document accepted on :2021-01-26
genomics
Document revised on :2020-12-23
phenomics
ISSN:2095-4689
2095-4697
DOI:10.15302/J-QB-021-0251