Is celecoxib an inducer of cytochrome P450 3A4 in subjects carrying the CYP2C93 allele?

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 80; no. 3; p. 298
Main Authors Rodrigues, A David, Yang, Zheng, Chen, Cliff, Pray, Devin, Kim, Sean, Sinz, Michael
Format Journal Article
LanguageEnglish
Published United States 01.09.2006
Subjects
Alleles
Area Under Curve
Aryl Hydrocarbon Hydroxylases - genetics
Aryl Hydrocarbon Hydroxylases - metabolism
Celecoxib
Cell Line, Tumor
Cyclooxygenase 2 Inhibitors - administration & dosage
Cyclooxygenase 2 Inhibitors - pharmacokinetics
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System - genetics
Cytochrome P-450 Enzyme System - metabolism
Gene Expression Regulation, Enzymologic - drug effects
Humans
Pyrazoles - administration & dosage
Pyrazoles - pharmacokinetics
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sulfonamides - administration & dosage
Sulfonamides - pharmacokinetics
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ISSN:0009-9236
DOI:10.1016/j.clpt.2006.05.009