Cyclodextrin-anionic polysaccharide hydrogels: Synthesis, characterization, and interaction with some organic molecules (water pollutants, drugs, proteins)

• Published in: Journal of applied polymer science Vol. 112; no. 3; pp. 1175 - 1183
• Main Authors: Mocanu, G, Mihai, D, LeCerf, D, Picton, L, Moscovici, M
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 05.05.2009; Wiley
• Subjects: Analytical chemistry; anionic pullulan; Applied sciences; Biological and medical sciences; Chemical Sciences; Chemistry; Chromatographic methods and physical methods associated with chromatography; chromatographic supports; cyclodextrins; Exact sciences and technology; General pharmacology; Medical sciences; microparticles; Natural polymers; Organic polymers; Other chromatographic methods; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Polymers; Properties and characterization; Solution and gel properties; Starch and polysaccharides; Swelling; Enzyme; Control release polymer; anionic pullulan; chromatographic supports; Crosslinking; Organic silane; Drug carrier; microparticles; Experimental study; cyclodextrins; Chromatography; Protein; Polyelectrolyte; Cyclodextrin; Binding capacity; Preparation; Microgel; Oside polymer; Property structure relationship; Hydrogel; Silicon polymer; Stationary phase
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.29580

Hydrogel microparticles have been prepared through cocrosslinking of cyclodextrin and of anionic carboxymethyl or sulfopropyl pullulan with a new bifunctional reagent: 3-(glycidoxypropyl)trimethoxysilane. This reagent forms crosslinking both through grafting with the epoxy end on the OH polysaccharide and through hydrolysis and condensation of the methoxy silane groups from the other end. Samples of cyclodextrin/anionic polysaccharides with various amounts of crosslinking agent were prepared. Characterization of the hydrogel microparticles considered the water swelling behavior, porosity measurements, retention of biologically active substances, which can occur by their inclusion in cyclodextrin inner cavities and in the pores of hydrogels, as well as through the electrostatic forces toward anionic polyelectrolyte charges. Their improved retention of various organic molecules as water pollutants, drugs, enzymes, recommend them as chromatographic supports, supports for the separation/immobilization of enzymes or for controlled release systems.