An improved synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine
An improved seven-step synthesis of 4-chloro-7 H -pyrrolo[2,3- d ]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7 H -pyrrolo[2,3- d ]pyrimidine building block.
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| Published in | Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 54; no. 6; pp. 638 - 642 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.06.2018
Springer Nature Springer Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
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| Abstract | An improved seven-step synthesis of 4-chloro-7
H
-pyrrolo[2,3-
d
]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7
H
-pyrrolo[2,3-
d
]pyrimidine building block. |
|---|---|
| AbstractList | An improved seven-step synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7H-pyrrolo[2,3-d]pyrimidine building block. An improved seven-step synthesis of 4-chloro-7 H -pyrrolo[2,3- d ]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7 H -pyrrolo[2,3- d ]pyrimidine building block. |
| Audience | Academic |
| Author | Xu, Cheng-Tao Zhang, Yu-Liu Zhu, Yong Luo, Yu Liu, Ting |
| Author_xml | – sequence: 1 givenname: Yu-Liu surname: Zhang fullname: Zhang, Yu-Liu organization: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University – sequence: 2 givenname: Cheng-Tao surname: Xu fullname: Xu, Cheng-Tao organization: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University – sequence: 3 givenname: Ting surname: Liu fullname: Liu, Ting organization: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University – sequence: 4 givenname: Yong surname: Zhu fullname: Zhu, Yong organization: Suzhou Highfine Biotech Co., Ltd – sequence: 5 givenname: Yu surname: Luo fullname: Luo, Yu email: yluo@chem.ecnu.edu.cn organization: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University |
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| Keywords | synthesis ozonolysis pyrimidine Janus kinase inhibitor |
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| PublicationTitle | Chemistry of heterocyclic compounds (New York, N.Y. 1965) |
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| Snippet | An improved seven-step synthesis of 4-chloro-7
H
-pyrrolo[2,3-
d
]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is... An improved seven-step synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is... |
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| SubjectTerms | Chemistry Chemistry and Materials Science Chemistry, Organic Organic Chemistry Pharmacy Physical Sciences Pyrimidines Science & Technology Synthesis |
| Title | An improved synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine |
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