An improved synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine

An improved seven-step synthesis of 4-chloro-7 H -pyrrolo[2,3- d ]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7 H -pyrrolo[2,3- d ]pyrimidine building block.

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Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 54; no. 6; pp. 638 - 642
Main Authors Zhang, Yu-Liu, Xu, Cheng-Tao, Liu, Ting, Zhu, Yong, Luo, Yu
Format Journal Article
LanguageEnglish
Published New York Springer US 01.06.2018
Springer Nature
Springer
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Organic Chemistry
Pharmacy
Physical Sciences
Pyrimidines
Science & Technology
Synthesis
synthesis
ozonolysis
pyrimidine
Janus kinase inhibitor
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Summary:An improved seven-step synthesis of 4-chloro-7 H -pyrrolo[2,3- d ]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7 H -pyrrolo[2,3- d ]pyrimidine building block.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-018-2320-0