Deep-brain stimulation

Deep-brain stimulation (DBS) is a clinical intervention that has provided remarkable therapeutic benefits for otherwise treatment-resistant movement and affective disorders. The resulting direct causal manipulation of both local and distributed brain networks is not only clinically helpful but can a...

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Bibliographic Details
Published inFuture Neurology Vol. 2; no. 6; pp. 633 - 646
Main Authors Kringelbach, Morten L, Owen, Sarah LF, Aziz, Tipu Z
Format Journal Article Book Review
LanguageEnglish
Published London Future Medicine Ltd 01.11.2007
Subjects
chronic pain
dystonia
essential tremor
globus pallidus interna
local field potentials
magnetoencephalography
neuroimaging
obsessive-–compulsive disorder
Parkinson ’s disease
pedunculopontine nucleus
subthalamic nucleus
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Summary:Deep-brain stimulation (DBS) is a clinical intervention that has provided remarkable therapeutic benefits for otherwise treatment-resistant movement and affective disorders. The resulting direct causal manipulation of both local and distributed brain networks is not only clinically helpful but can also help to provide novel fundamental insights into brain function. In particular, DBS can be used in conjunction with methods such as local field potentials and magnetoencephalography to map the underlying mechanisms of normal and abnormal oscillatory synchronization in the brain. The precise mechanisms of action for DBS remain uncertain but here we present an overview of the clinical efficacy of DBS, its neural mechanisms and potential future applications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1479-6708
1748-6971
DOI:10.2217/14796708.2.6.633