Synthesis and Cytotoxic Activity of Tetrazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones

Tetrazole-containing 1,5,6,7-tetrahydro-4 H- indazol-4-ones were synthesized by condensation of 2-(tetrazolylacetyl)cyclohexane-1,3-diones with phenyl- or 4-fluorophenylhydrazines in ethanol at room temperature. Structure of the synthesized compounds were confirmed by 1 H, 13 C, 19 F NMR spectroscop...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 92; no. 3; pp. 359 - 366
Main Authors Khlebniсova, T. S., Zinovich, V. G., Piven, Yu. A., Baranovsky, A. V., Lakhvich, F. A., Trifonov, R. E., Golubeva, Yu. A., Lider, E. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.03.2022
Springer Nature
Springer
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Cyclohexane
Cytotoxicity
Ethanol
NMR spectroscopy
Nuclear magnetic resonance spectroscopy
Physical Sciences
Room temperature
Science & Technology
Synthesis
Tetrazoles
indazol-4-ones
2-(tetrazolylacetyl)cyclohexane-1,3-diones
cytotoxic activity
1,5,6,7-tetrahydro-4
tetrazoles
Hep2
7-tetrahydro-4H-indazol-4-ones
ANTITUMOR
DISCOVERY
1
5
2-(tetrazolylacetyl)cyclohexane-1
6
3-diones
N-15 NMR
INHIBITORS
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Summary:Tetrazole-containing 1,5,6,7-tetrahydro-4 H- indazol-4-ones were synthesized by condensation of 2-(tetrazolylacetyl)cyclohexane-1,3-diones with phenyl- or 4-fluorophenylhydrazines in ethanol at room temperature. Structure of the synthesized compounds were confirmed by 1 H, 13 C, 19 F NMR spectroscopy methods. Cytotoxic activity of the series of obtained compounds was investigated in vitro against human laryngeal cancer cells Hep2.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363222030045