Harnessing the pancreatic stem cell

Building on the elaborate research studies that have helped map out key decision points in the process of pancreas development, reprogramming of pluripotent embryonic stem cells or induced pluripotent stem cells offers the possibility of overcoming restrictions on tissue supply associated with trans...

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Bibliographic Details
Published inEndocrinology and metabolism clinics of North America Vol. 39; no. 4; p. 763
Main Authors Taylor-Fishwick, David A, Pittenger, Gary L
Format Journal Article
LanguageEnglish
Published United States 01.12.2010
Subjects
Animals
Cell Differentiation - physiology
Embryonic Development - physiology
Embryonic Stem Cells - physiology
Female
Humans
Insulin-Secreting Cells - cytology
Insulin-Secreting Cells - physiology
Models, Biological
Pancreas - embryology
Pancreas - growth & development
Pancreas - physiology
Pregnancy
Regenerative Medicine - methods
Regenerative Medicine - trends
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Summary:Building on the elaborate research studies that have helped map out key decision points in the process of pancreas development, reprogramming of pluripotent embryonic stem cells or induced pluripotent stem cells offers the possibility of overcoming restrictions on tissue supply associated with transplantation of donor islets. In a healthy pancreas, the beta-cell mass can exhibit significant plasticity, as reflected in the normal adaptive response in beta-cell mass to offset the metabolic challenge associated with pregnancy and obesity. In this article, alternative strategies and potential sources of pancreatic stem cells are considered.
ISSN:1558-4410
DOI:10.1016/j.ecl.2010.08.008