Treatment of locally advanced squamous cell carcinoma of the head and neck with concurrent bleomycin and external beam radiation therapy

Nineteen patients with advanced head and neck cancer were treated with bleomycin (15u BM and irradiation (180 rad, 5d/week, 5040 rad) and have analyzed the effects. Most patients went on to further radical treatment. Both epithelial toxicity and tumor regression seemed enhanced. Approaching 1 year m...

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Bibliographic Details
Published inInternational journal of radiation oncology, biology, physics Vol. 5; no. 9; pp. 1531 - 1535
Main Authors Seagren, Stephen L, Byfield, John E, Nahum, Alan M, Bone, Robert C
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.1979
Subjects
Aged
Bleomycin
Bleomycin - adverse effects
Bleomycin - therapeutic use
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - radiotherapy
Dermatitis - etiology
Female
Head and neck cancer
Head and Neck Neoplasms - drug therapy
Head and Neck Neoplasms - radiotherapy
Humans
Male
Middle Aged
Mucous Membrane - drug effects
Mucous Membrane - radiation effects
Necrosis - etiology
Radiation
Radiation Injuries
Radioisotope Teletherapy
Remission, Spontaneous
Time Factors
Head and neck cancer
Bleomycin
Radiation
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Summary:Nineteen patients with advanced head and neck cancer were treated with bleomycin (15u BM and irradiation (180 rad, 5d/week, 5040 rad) and have analyzed the effects. Most patients went on to further radical treatment. Both epithelial toxicity and tumor regression seemed enhanced. Approaching 1 year minimum follow-up (2 years maximum) crude survival is 68% and disease-free survival is 57%. Late complications do not seem to be enhanced. Regression in advanced nodal disease was less impressive.
ISSN:0360-3016
1879-355X
DOI:10.1016/0360-3016(79)90765-X