Antibody and complement levels in patients with hypersplenism associated with cirrhotic portal hypertension and therapeutic principles
Hypersplenism associated with cirrhotic portal hypertension is a common condition often resulting from hepatitis B-related cirrhosis. However, the levels of immunoglobulin (Ig) and complement in patients with hypersplenism associated with cirrhotic portal hypertension remain unclear. This study was...
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Published in | World journal of clinical cases Vol. 10; no. 36; pp. 13208 - 13215 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
26.12.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Hypersplenism associated with cirrhotic portal hypertension is a common condition often resulting from hepatitis B-related cirrhosis. However, the levels of immunoglobulin (Ig) and complement in patients with hypersplenism associated with cirrhotic portal hypertension remain unclear. This study was undertaken to determine the levels of Ig and complement in these patients, the relationship between these levels and Child-Pugh class and their clinical significance.
To investigate the antibody (Ig) and complement levels in patients with hypersplenism associated with cirrhotic portal hypertension and their clinical significance.
Clinical data of 119 patients with hypersplenism associated with cirrhotic portal hypertension were statistically analyzed and compared with those of 128 control patients.
IgA and IgG levels in patients with hypersplenism were significantly higher than controls (
< 0.001). There was no significant difference in IgM between the two groups (
= 0.109). C3 and C4 levels in patients with hypersplenism were significantly lower than controls (
< 0.001). As liver function decreased, IgA and IgG levels increased (
< 0.001), and C3 and C4 levels decreased (
< 0.001).
Patients with hypersplenism associated with cirrhotic portal hypertension have significantly higher antibody (IgA and IgG) levels and significantly lower complement (C3 and C4) levels, which are both related to liver damage. Clinically, the administration of anti-hepatitis virus agents and protection of liver function should be strengthened. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: Zhang K, Zeng M, Li YJ, Wu JC, Zheng JF and Lv YF contributed equally to this work; Lv YF was responsible for project design and thesis writing; Zhang K and Li YJ were responsible for implementation and statistical information; Wu JC, Zheng JF and Zeng M were responsible for data and statistical information collection; Wu HF and Zhang ZS participated in data collection and registration; all authors have read this article and consent to publication. Supported by Hainan Provincial Department of Science and Technology, Qiongke[2020]256. Corresponding author: Yun-Fu Lv, Doctor, MD, PhD, Academic Research, Chief Doctor, Professor, Research Scientist, Surgeon, Department of General Surgery, Hainan General Hospital, No. 19 Xiuhua Road, Xiuyin District, Haikou 570311, Hainan Province, China. yunfu_lv@126.com |
ISSN: | 2307-8960 2307-8960 |
DOI: | 10.12998/wjcc.v10.i36.13208 |