Methyl Trifluoropyruvate Pyrazin-2-ylimine in Cyclocondensation and Cycloaddition Reactions

The transformations of methyl trifluoropyruvate pyrazin-2-ylimine in the cyclocondensation reactions with 2-aminothiazoline, amidines, aminocrotonitrile and aza-Diels—Alder reactions with cyanamines, leading to five- and six-membered trifluoromethyl-containing heterocycles, were studied. The possibi...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 89; no. 2; pp. 364 - 367
Main Authors Sokolov, V. B., Aksinenko, A. Yu
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.02.2019
Springer Nature
Springer
Springer Nature B.V
Subjects
Alkynes
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Cycloaddition
Diels-Alder reaction
Letters to the Editor
Lipid peroxidation
Physical Sciences
Science & Technology
phenothiazine
aminocrotonitrile
2-aminothiazoline
aza-Diels—Alder reaction
cyanamines
benzamidines
methyl trifluoropyruvate pyrazin-2-ylimine
1,3-dipolar cycloaddition
aza-DielsAlder reaction
3-dipolar cycloaddition
KINASE
PYRAZINE
1
INHIBITORS
BINDING
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Summary:The transformations of methyl trifluoropyruvate pyrazin-2-ylimine in the cyclocondensation reactions with 2-aminothiazoline, amidines, aminocrotonitrile and aza-Diels—Alder reactions with cyanamines, leading to five- and six-membered trifluoromethyl-containing heterocycles, were studied. The possibility of using 4-(pyrazin-2-ylamino)-1-(prop-2-yn-1-yl)-4-(trifluoromethyl)-1 H -imidazol-5(4 H )-one, the product of methyl trifluoropyruvate pyrazin-2-ylimine cyclocondensation, for modification of phenothiazine by copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition was shown.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219020300