Bimetallic Copper-Heme-Protein-DNA Hybrid Catalyst for Diels Alder Reaction

A bimetallic heme-DNA cofactor, containing an iron and a copper center, was synthesized for the design of novel hybrid catalysts for stereoselective synthesis. The cofactor was used for the reconstitution of apo-myoglobin. Both the cofactor alone and its myoglobin adduct were used to catalyze a mode...

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Published inCroatica Chemica Acta Vol. 84; no. 2; pp. 269 - 275
Main Authors Kuo, Chi-Hsien, Niemeyer, Christof M, Fruk, Ljiljana
Format Journal Article Paper
LanguageEnglish
Croatian
Published Zagreb Croatica Chemica Acta, Croatian Chemical Society 01.01.2011
Hrvatsko kemijsko društvo
Subjects
Biochemistry
bioorganic chemistry
Catalysis
Chemical reactions
Chemical synthesis
Deoxyribonucleic acid
DNA
DNA-protein conjugates
stereoselective catalysis
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Summary:A bimetallic heme-DNA cofactor, containing an iron and a copper center, was synthesized for the design of novel hybrid catalysts for stereoselective synthesis. The cofactor was used for the reconstitution of apo-myoglobin. Both the cofactor alone and its myoglobin adduct were used to catalyze a model Diels Alder reaction. Stereoselectivity of this conversion was analyzed by chiral HPLC. Reactions carried out in the presence of myoglobin-heme-Cu-DNA catalyst showed greater product conversion and stereoselectivity than those carried out with the heme-Cu-DNA cofactor. This observation suggested that the protein shell plays a significant role in the catalytic conversion. [PUBLICATION ABSTRACT]
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
71990
ISSN:0011-1643
1334-417X
DOI:10.5562/cca1828