Perinatal outcome in women with severe pregnancy complications and multiple thrombophilias

• Published in: Journal of perinatal medicine Vol. 32; no. 3; pp. 225 - 227
• Main Authors: Kupferminc, M.J., Rimon, E., Ascher-Landsberg, J., Lessing, J.B., Many, A.
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter 01.01.2004; New York, NY De Gruyter
• Subjects: Abruptio Placentae - epidemiology; Abruptio Placentae - etiology; Abruptio Placentae - pathology; Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Birth Weight; Case-Control Studies; Delivery. Postpartum. Lactation; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Female; Fetal Growth Retardation - epidemiology; Fetal Growth Retardation - etiology; Fetal Growth Retardation - pathology; Gestational Age; Gynecology. Andrology. Obstetrics; Humans; Infant, Newborn; Intensive care medicine; Israel - epidemiology; Medical sciences; Pre-Eclampsia - epidemiology; Pre-Eclampsia - etiology; Pre-Eclampsia - pathology; Pregnancy; Pregnancy Complications, Hematologic - epidemiology; Pregnancy Complications, Hematologic - etiology; Pregnancy Complications, Hematologic - pathology; Pregnancy Outcome; Severity of Illness Index; Thrombophilia - epidemiology; Thrombophilia - etiology; Thrombophilia - pathology; Israel; Human; Thrombophilia; Multiple; Newborn; Prognosis; Multiple pregnancy; Neonatology; Perinatal; Complication; Evolution; Female; Woman
• ISSN: 0300-5577; 1619-3997
• DOI: 10.1515/JPM.2004.042

Hypercoagulability leading to placental thrombosis has been implicated in severe pregnancy complications. We compared the perinatal outcome in women with severe preeclampsia, intrauterine growth retardation (IUGR) and severe abruptio placentae and multiple acquired and inherited thrombophilias (study group, n=22) to matched women with similar complications and single thrombophilia (control group, n=22). Gestational age at delivery and birth weight were significantly lower in the study group compared to the control group (p<0.01) and among the study women with severe preeclampsia and IUGR. Severe pregnancy complications may occur earlier during pregnancy and more seriously affect perinatal outcome in women with multiple thrombophilias.