1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity

Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted 2-benzylaminobenzimidazoles. The Microcosm information technology (IT) tool was used to assess in silico the potential f...

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Published inPharmaceutical chemistry journal Vol. 49; no. 11; pp. 735 - 742
Main Authors Zhukovskaya, O. N., Anisimova, V. A., Spasov, A. A., Vasil’ev, P. M., Kosolapov, V. A., Kucheryavenko, A. F., Gurova, N. A., Naumenko, L. V., Kuznetsova, V. A., Sorotskii, D. V., Solov’eva, O. A., Reznikov, E. V., Gurova, V. V., Sirotenko, V. S.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.02.2016
Springer
Subjects
Antiarrhythmia agents
Antioxidants (Nutrients)
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Schiff bases
synthesis
experimental study
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1-substituted 2-benzylaminobenzimidazoles
Microcosm IT tool
antiarrhythmic, antiaggregant, antioxidant, hemorheologic, and antiglycating activity
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Summary:Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted 2-benzylaminobenzimidazoles. The Microcosm information technology (IT) tool was used to assess in silico the potential for antiarrhythmic, antiaggregant, antioxidant, hemorheologic, and antiglycating activity in this series of compounds. Pharmacological screening identified which of the synthesized compounds were active. It was shown that the computer predictions correlated with the experimental data.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-016-1362-9