Synthesis of new pyrrolo[2,1-a]phthalazine derivatives via multicomponent reaction of phthalazine with 1,1-dicyanoalkenes and alkyl isocyanides

Multicomponent reactions between phthalazine, alkyl isocyanides, and 1,1-dicyanoalkenes in acetonitrile–water mixture produced high yields of substituted pyrrolo[2,1- a ]phthalazines, which were converted upon treatment with 10% hydrochloric acid to pyrrolo[2,1- a ]-phthalazines unsubstituted at pos...

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Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 53; no. 4; pp. 430 - 433
Main Authors Mironov, Maxim A., Shulepov, Iliya D., Kozhikhova, Ksenia V., Ivantsova, Maria N., Tokareva, Maria I.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.04.2017
Springer Nature
Springer
Springer Nature B.V
Subjects
Alkyl groups
Biphenyl (Compound)
Chemical reactions
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Hydrochloric acid
Nitriles
Optical properties
Organic Chemistry
Pharmacy
Physical Sciences
Science & Technology
phthalazine
isocyanides
decarboxylation
multicomponent reaction
one-pot synthesis
CYCLOADDITIONS
FLUORESCENT PYRROLOPYRIDAZINE DERIVATIVES
WATER
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Summary:Multicomponent reactions between phthalazine, alkyl isocyanides, and 1,1-dicyanoalkenes in acetonitrile–water mixture produced high yields of substituted pyrrolo[2,1- a ]phthalazines, which were converted upon treatment with 10% hydrochloric acid to pyrrolo[2,1- a ]-phthalazines unsubstituted at position 1. As a result, a range of new pyrrolo[2,1- a ]phthalazine derivatives have been synthesized by this one-pot approach.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-017-2071-3