Pyridinoline, a mature collagen cross-link, in fibrotic livers from Schistosoma mansoni-infected mice

The amount of pyridinoline, a cross-linking amino acid found in mature collagen, was measured in murine liver for a period of up to 40 weeks following Schistosoma mansoni infection. The pyridinoline level (expressed as pmol per 100 micrograms of liver) markedly increased in the course of murine schi...

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Bibliographic Details
Published inThe American journal of tropical medicine and hygiene Vol. 47; no. 6; p. 816
Main Authors Ricard-Blum, S, Ville, G, Grimaud, J A
Format Journal Article
LanguageEnglish
Published United States 01.12.1992
Subjects
Amino Acids - analysis
Animals
Collagen - analysis
Collagen - metabolism
Cross-Linking Reagents
Female
Liver - chemistry
Liver - pathology
Liver Cirrhosis - etiology
Liver Cirrhosis - metabolism
Liver Diseases, Parasitic - metabolism
Mice
Mice, Inbred BALB C
Schistosomiasis mansoni - complications
Schistosomiasis mansoni - metabolism
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Summary:The amount of pyridinoline, a cross-linking amino acid found in mature collagen, was measured in murine liver for a period of up to 40 weeks following Schistosoma mansoni infection. The pyridinoline level (expressed as pmol per 100 micrograms of liver) markedly increased in the course of murine schistosomiasis, and the number of pyridinoline residues per collagen molecule was also higher in the livers of infected mice than that of control livers. This increase in the extent of intermolecular collagen cross-linking might play a role in the modulation of collagen catabolism as an auxiliary mechanism of extracellular matrix accumulation during fibrogenesis.
ISSN:0002-9637
DOI:10.4269/ajtmh.1992.47.816