Topotaxis of active Brownian particles

• Published in: Physical review. E Vol. 101; no. 3-1; p. 032602
• Main Authors: Schakenraad, Koen, Ravazzano, Linda, Sarkar, Niladri, Wondergem, Joeri A J, Merks, Roeland M H, Giomi, Luca
• Format: Journal Article
• Language: English
• Published: United States 01.03.2020
• ISSN: 2470-0053
• DOI: 10.1103/PhysRevE.101.032602

Recent experimental studies have demonstrated that cellular motion can be directed by topographical gradients, such as those resulting from spatial variations in the features of a micropatterned substrate. This phenomenon, known as topotaxis, has been extensively studied for topographical gradients at the subcellular scale, but can also occur in the presence of a spatially varying density of cell-sized features. Such a large-scale topotaxis has recently been observed in highly motile cells that persistently crawl within an array of obstacles with smoothly varying lattice spacing. We introduce a toy model of large-scale topotaxis, based on active Brownian particles. Using numerical simulations and analytical arguments, we demonstrate that topographical gradients introduce a spatial modulation of the particles' persistence, leading to directed motion toward regions of higher persistence. Our results demonstrate that persistent motion alone is sufficient to drive large-scale topotaxis and could serve as a starting point for more detailed studies on self-propelled particles and cells.