Axonal and Neuronal Amyloid Precursor Protein Immunoreactivity in the Brains of Guinea Pigs Given Tunicamycin

Amyloid precursor protein (APP) immunocytochemistry was used to study axonal and neuronal changes in guinea pig brains exposed to tunicamycin. Substantial axonal injury was found in ischemic-hypoxic foci and more generally, but this injury was not readily appreciable in conventionally stained sectio...

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Bibliographic Details
Published inVeterinary pathology Vol. 37; no. 6; pp. 677 - 680
Main Authors Finnie, J. W., Manavis, J., Blumbergs, P. C., Kuchel, T. R.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.11.2000
Subjects
Amyloid beta-Protein Precursor - metabolism
Animals
Anti-Bacterial Agents - toxicity
Axons - chemistry
Axons - drug effects
Brain - drug effects
Brain Chemistry - drug effects
Guinea Pigs - metabolism
Immunohistochemistry - veterinary
Neurons - chemistry
Neurons - drug effects
Tunicamycin - toxicity
Amyloid precursor protein immunohistochemistry
pigs
axonal and neuronal changes
guinea
brain
tunicamycin
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Summary:Amyloid precursor protein (APP) immunocytochemistry was used to study axonal and neuronal changes in guinea pig brains exposed to tunicamycin. Substantial axonal injury was found in ischemic-hypoxic foci and more generally, but this injury was not readily appreciable in conventionally stained sections. Neuronal perikaryal APP expression was also widely distributed, possibly as an acute phase response to this neurotoxin.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.37-6-677