WEB-server for search of a periodicity in amino acid and nucleotide sequences

A new web server (http://victoria.biengi.ac.ru/splinter/login.php) was designed and developed to search for periodicity in nucleotide and amino acid sequences. The web server operation is based upon a new mathematical method of searching for multiple alignments, which is founded on the position weig...

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Bibliographic Details
Published inJournal of physics. Conference series Vol. 937; no. 1; pp. 12013 - 12019
Main Authors Frenkel, F E, Skryabin, K G, Korotkov, E V
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.12.2017
Subjects
Access control
Amino acids
Dynamic programming
Mathematical analysis
Nucleotides
Optimization
Physics
Sequences
Servers
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Summary:A new web server (http://victoria.biengi.ac.ru/splinter/login.php) was designed and developed to search for periodicity in nucleotide and amino acid sequences. The web server operation is based upon a new mathematical method of searching for multiple alignments, which is founded on the position weight matrices optimization, as well as on implementation of the two-dimensional dynamic programming. This approach allows the construction of multiple alignments of the indistinctly similar amino acid and nucleotide sequences that accumulated more than 1.5 substitutions per a single amino acid or a nucleotide without performing the sequences paired comparisons. The article examines the principles of the web server operation and two examples of studying amino acid and nucleotide sequences, as well as information that could be obtained using the web server.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/937/1/012013