4-hydroxy-2-quinolones. 197. The search for novel diuretics amongst halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline-5-carboxylic acid anilides

A targeted synthesis of a series of halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2-dihydro-4 H -pyrrolo-[3,2,1- ij ]quinoline-5-carboxylic acid anilides have been carried out. Peculiarites of the 1 H NMR spectra and the results of investigating the diuretic activity of these compounds are discussed.

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Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 47; no. 7; pp. 826 - 832
Main Authors Ukrainets, I. V., Golik, N. Yu, Shemchuk, A. L., Naboka, O. I., Voronina, Yu. V., Turov, A. V.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.10.2011
Springer Nature
Springer
Subjects
Alkaloids
Antihypertensive drugs
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Diuretics
Hypertension
Organic acids
Organic Chemistry
Pharmacy
Physical Sciences
Quinoline
Science & Technology
amidation
4-hydroxy-2-oxoquinoline-3-carboxylic acids
methylindoline
diuretic activity
anilides
TRIAL
PERINDOPRIL
HYPERTENSION
COMBINATION
BLOOD-PRESSURE
CEREBROVASCULAR-DISEASE
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Summary:A targeted synthesis of a series of halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2-dihydro-4 H -pyrrolo-[3,2,1- ij ]quinoline-5-carboxylic acid anilides have been carried out. Peculiarites of the 1 H NMR spectra and the results of investigating the diuretic activity of these compounds are discussed.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-011-0842-9