Effect of placenta previa on neonatal respiratory disorders and amniotic lamellar body counts at 36–38weeks of gestation

• Published in: Early human development Vol. 90; no. 1; pp. 51 - 54
• Main Authors: Tsuda, Hiroyuki, Kotani, Tomomi, Sumigama, Seiji, Mano, Yukio, Hua, Li, Hayakawa, Hiromi, Hayakawa, Masahiro, Sato, Yoshiaki, Kikkawa, Fumitaka
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.01.2014
• Subjects: Adult; Amniotic fluid; Amniotic Fluid - cytology; Case-Control Studies; Female; Humans; Infant, Newborn; Infant, Premature; Lamellar body; Male; Odds Ratio; Placenta previa; Placenta Previa - epidemiology; Placenta Previa - pathology; Pregnancy; Respiratory distress syndrome; Respiratory Distress Syndrome, Newborn - epidemiology; Respiratory Distress Syndrome, Newborn - etiology; Risk Factors; Transient tachypnea of the newborn; Transient Tachypnea of the Newborn - epidemiology; Transient Tachypnea of the Newborn - etiology; Transient tachypnea of the newborn; Placenta previa; Respiratory distress syndrome; Amniotic fluid; Lamellar body
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/j.earlhumdev.2013.10.005

Pregnancies with placenta previa are significantly associated with preterm delivery and cesarean section. Therefore particular attention should be paid to the incidence of neonatal respiratory disorders in pregnancies with placenta previa. The purpose of this study is to examine the relationship between placenta previa and neonatal respiratory disorders, including respiratory distress syndrome (RDS) and transient tachypnea of the newborn (TTN), and to evaluate the impact of placenta previa on the amniotic lamellar body count (LBC) values. We analyzed the data from 186 registered elective cesarean cases without fetal or maternal complications at 36–38weeks of gestation. Amniotic fluid samples were analyzed immediately without centrifugation, and the LBC was measured using a platelet channel on the Sysmex XE-2100. RDS was present in four neonates (2.2%) and TTN in 12 neonates (6.5%). The rate of TTN was significantly higher and the LBC values were significantly lower in the placenta previa group than in the control group (P=0.002 and P=0.024). The adjusted odds ratio for neonatal TTN was 7.20 (95% confidence interval: 6.58–7.88) among females with placenta previa. In placenta previa, warning bleeding was a significant factor protecting against neonatal respiratory disorders (P=0.046). Placenta previa in itself is a risk factor for neonatal TTN. When an elective cesarean section is performed in cases with uncomplicated placenta previa, special care should be taken to monitor for neonatal TTN even at 36–38weeks of gestation.