Impairment of enzyme induction by glucocorticoids in Zajdela hepatoma cells

Whereas glucocorticoids induce TAT, TRP, GPT in liver and only TAT in HTC cells, no hormonal effect on the synthesis of these enzymes was found in Zajdela hepatoma cells grown in vivo as an ascitie tumor, or in vitro as layer cultures. Although these cells remain uninducible, the hormone penetrates...

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Published inCell differentiation Vol. 5; no. 4; pp. 255 - 262
Main Authors Befort, Jean-Jacques, Befort, Nicole, Beck, Jean-Paul, Beck, Gisele, Defer, Nicole, Kruh, Jacques
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 01.12.1976
Subjects
Alanine Transaminase - biosynthesis
Animals
Aspartate Aminotransferases - biosynthesis
Carcinoma, Hepatocellular - metabolism
Cell Line
Cytosol - metabolism
Dexamethasone - metabolism
Dexamethasone - pharmacology
Dimethyl Sulfoxide - pharmacology
Dimethylformamide - pharmacology
Enzyme Induction - drug effects
Liver Neoplasms
Neoplasms, Experimental - metabolism
Nucleoproteins - metabolism
Rats
Tryptophan Oxygenase - biosynthesis
Tyrosine Transaminase - biosynthesis
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Summary:Whereas glucocorticoids induce TAT, TRP, GPT in liver and only TAT in HTC cells, no hormonal effect on the synthesis of these enzymes was found in Zajdela hepatoma cells grown in vivo as an ascitie tumor, or in vitro as layer cultures. Although these cells remain uninducible, the hormone penetrates normally, but a strong decrease of the specific binding of cytosol and nuclear proteins with the hormone was observed. The impairment at the level of the hormone receptors could account for the non-inducibility of enzyme synthesis in ZHC cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0045-6039
DOI:10.1016/0045-6039(76)90036-1