Comparison of immunoaffinity chromatography combined with gas chromatography—negative ion chemical ionisation mass spectrometry and radioimmunoassay for screening dexamethasone in equine urine

A comparison of the sensitive analytical methods of radioimmunoassay (RIA) and immunoaffinity chromatography (IAC) combined with gas chromatography—negative ion chemical ionisation mass spectrometry for the specific and reliable screening of dexamethasone in equine post-race urine is presented. Resu...

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Bibliographic Details
Published inJournal of chromatography Vol. 620; no. 2; pp. 250 - 253
Main Authors Stanley, S.M.R., Wilhelmi, B.S., Rodgers, J.P.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 29.10.1993
Elsevier
Subjects
Analysis
Animals
Biological and medical sciences
Chromatography, Affinity - methods
Dexamethasone - urine
Doping in Sports
Female
Gas Chromatography-Mass Spectrometry
General pharmacology
Horses - urine
Medical sciences
Oxidation-Reduction
Pharmacology. Drug treatments
Radioimmunoassay
Urine
Corticosteroid
Dexamethasone
Immunoaffinity chromatography
Coupled method
Chemical ionization
Gas chromatography
Vertebrata
Mammalia
Animal
Radioimmunoassay
Horse
Negative ion
Perissodactyla
Veterinary
Mass spectrometry
Ungulata
Comparative study
Quantitative analysis
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Summary:A comparison of the sensitive analytical methods of radioimmunoassay (RIA) and immunoaffinity chromatography (IAC) combined with gas chromatography—negative ion chemical ionisation mass spectrometry for the specific and reliable screening of dexamethasone in equine post-race urine is presented. Results from analyses of samples collected from a mare during 144 hours post administration of 26 mg of dexamethasone sodium phosphate are described.
ISSN:0378-4347
DOI:10.1016/0378-4347(93)80012-S