Constituents from Hoya parasitica and their cell growth inhibitory activity

An androstanoid, hoyasterone (1), a sesquiterpene, 15-bulnesolic acid (2), and a phenolic compound, 1-(4-hydroxy-3-methoxyphenyl)-1-methoxypropan-2-ol (3), together with a known triterpene, dihydrocanaric acid, were isolated from Hoya parasitica. Structures were elucidated by 1 D and 2 D NMR and mas...

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Bibliographic Details
Published inPlanta medica Vol. 74; no. 7; pp. 760 - 763
Main Authors Sadhu, S.K, Khatun, A, Ohtsuki, T, Ishibashi, M
Format Journal Article
LanguageEnglish
Published Germany 01.06.2008
Subjects
androstanoid
anticarcinogenic activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Apocynaceae - chemistry
bulnesolic acid
cell growth
Cell Proliferation - drug effects
chemical constituents of plants
chemical structure
cultured cells
HeLa Cells
Hoya
Hoya parasitica
hoyasterone
Humans
medicinal plants
Molecular Structure
phenolic compounds
sesquiterpenoids
spectral analysis
Bangladesh
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Summary:An androstanoid, hoyasterone (1), a sesquiterpene, 15-bulnesolic acid (2), and a phenolic compound, 1-(4-hydroxy-3-methoxyphenyl)-1-methoxypropan-2-ol (3), together with a known triterpene, dihydrocanaric acid, were isolated from Hoya parasitica. Structures were elucidated by 1 D and 2 D NMR and mass spectroscopic analysis. Among the isolated compounds, only dihydrocanaric acid exhibited growth inhibitory activity against both HeLa and SW480 cells.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2008-1074523