Pharmacokinetics and pharmacodynamics of ceftizoxime in abscess fluid

Ceftizoxime was found to penetrate readily into abscess fluid, with levels ranging from 2 to 30 mg/L. The highest concentrations were noted in patients receiving 2.0 g doses or associated with more long-term therapy. Organisms included: Staphylococcus aureus (methicillin-resistant), yeasts, Bacteroi...

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Bibliographic Details
Published inJournal of antimicrobial chemotherapy Vol. 39; no. 3; pp. 437 - 438
Main Authors Guglielmo, B J, Kostiuk, K A, Pons, V G
Format Journal Article
LanguageEnglish
Published England 01.03.1997
Subjects
Abdominal Abscess - metabolism
Abscess - metabolism
Adolescent
Adult
Aged
Bacteroides
Brain Abscess - metabolism
Ceftizoxime - pharmacokinetics
Ceftizoxime - pharmacology
Enterococcus
Humans
Middle Aged
Nocardia asteroides
Streptococcus viridans
Staphylococcus aureus
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Summary:Ceftizoxime was found to penetrate readily into abscess fluid, with levels ranging from 2 to 30 mg/L. The highest concentrations were noted in patients receiving 2.0 g doses or associated with more long-term therapy. Organisms included: Staphylococcus aureus (methicillin-resistant), yeasts, Bacteroides, Streptococcus viridans, Enterococcus, Nocardia asteroides, and S. aureus (methicillin-susceptible).
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ISSN:0305-7453
1460-2091
DOI:10.1093/jac/39.3.437