The development and application of glyco-probes for bovine serum albumin

Two glyco-probes, GFP and GFN, which are derived from the condensation of 3-acetyl-5-C-(2,3-dihydroxy-1,4-anhydro-β-D-erythro-tetrofuranosyl)-2-methylfuran with benzaldehyde and 1-naphthaldehyde, respectively, are designed and synthesized. Of these two probes, GFP displays a selective and sensitive...

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Bibliographic Details
Published inJournal of chemical research Vol. 47; no. 3; p. 174751982311779
Main Authors Gu, Xiaomin, Ji, Fei, Jiang, Dawei, Liang, Wenhui, Feng, Yan, Niu, Shanshan, Zhao, Qiang
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.05.2023
Sage Publications Ltd
Subjects
Benzaldehyde
Cattle
Displays
Fluorescence
Serum albumin
glyco-probe
selective
fluorescence
bovine serum albumin
carbohydrate
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Summary:Two glyco-probes, GFP and GFN, which are derived from the condensation of 3-acetyl-5-C-(2,3-dihydroxy-1,4-anhydro-β-D-erythro-tetrofuranosyl)-2-methylfuran with benzaldehyde and 1-naphthaldehyde, respectively, are designed and synthesized. Of these two probes, GFP displays a selective and sensitive switch-on fluorescence response towards bovine serum albumin in phosphate-buffered saline over a wide pH range. Moreover, the fluorescence of this probe displays a good linear relationship with the bovine serum albumin concentration ranging from 0 to 0.8 mg/mL, and has a limit of detection as low as 3.7 nM. The stoichiometric ratio of bovine serum albumin /GFP is 1:1. This research paves the way for the development of glyco-probes for bovine serum albumin sensing.
ISSN:1747-5198
2047-6507
DOI:10.1177/17475198231177954