Recent advances in radiotherapy and its associated side effects in cancer—a review

Background Radiotherapy (RT) is the chief nonsurgical method to control malignant tumors. RT has advanced in both methodological and biological aspects over the past few decades. Though RT is a momentous adjuvant non-invasive technique, it leaves behind some unsympathetic effects. Research is going...

Full description

Saved in:
Bibliographic Details
Published inJournal of basic & applied zoology Vol. 80; no. 1; pp. 1 - 10
Main Authors Mohan, Gomathi, T P, Ayisha Hamna, A J, Jijo, K M, Saradha Devi, Narayanasamy, Arul, Vellingiri, Balachandar
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 27.02.2019
Springer Nature B.V
SpringerOpen
Subjects
Biomedical and Life Sciences
Cancer
Cell Biology and Genetics
Infertility
Life Sciences
Literature reviews
Mutational changes
Radiation therapy
Radiosensitizers
Radiotherapy
Review
Secondary malignancy
Side effects
Tumors
Zoology
Secondary malignancy
Radiotherapy
Mutational changes
Infertility
Cancer
Online AccessGet full text

Cover

More Information
Summary:Background Radiotherapy (RT) is the chief nonsurgical method to control malignant tumors. RT has advanced in both methodological and biological aspects over the past few decades. Though RT is a momentous adjuvant non-invasive technique, it leaves behind some unsympathetic effects. Research is going on to surmount these pessimistic sides of RT. Methods We made a mini review of recent articles from the period of 2000 to 2017 regarding radiotherapy and its side effects in various types of cancers. The literature review was done by searching in PUBMED, MEDLINE, and SCOPUS. Results Here, we spotlight the physiological and genetic risks associated with the cancer patients undergoing RT. We illustrated the course of RT in most prevalent cancers tailored with dosage distribution. Radiation-induced mutation in the patients undergoing RT has been shown with evidence. Further, the major drawbacks like the development of radiation resistance in cancerous cells and secondary malignancies have been discussed. The problems associated with radiation dosage in terms of infertility and rejuvenation of reproductive cells has also been discussed. Finally, we discussed the latest treatment stratagem of RT in cancer. Conclusion Cancer treatment will not be accomplished devoid of radiotherapy. But we can brace RT using radiosensitizers and ayurvedic radioprotectors.
ISSN:2090-990X
2090-990X
DOI:10.1186/s41936-019-0083-5