Evaluation of intermittent infusion of bupivacaine into surgical wounds of dogs postoperatively

• Published in: The veterinary journal (1997) Vol. 190; no. 2; pp. 287 - 289
• Main Authors: Hardie, Elizabeth M., Lascelles, B. Duncan X., Meuten, Travis, Davidson, Gigi S., Papich, Mark G., Hansen, Bernie D.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2011
• Subjects: Analgesia; Anesthetics, Local - pharmacokinetics; Anesthetics, Local - therapeutic use; Animals; Bupivacaine; Bupivacaine - pharmacokinetics; Bupivacaine - therapeutic use; Dog; Dogs - surgery; Double-Blind Method; Infusions, Intralesional - veterinary; Local anesthesia; Pain Measurement - veterinary; Pain, Postoperative - drug therapy; Pain, Postoperative - veterinary; Post-operative pain; Postoperative Care - veterinary; Prospective Studies; Recovery of Function; Wound Healing; Wound infusion; Analgesia; Post-operative pain; Bupivacaine; Dog; Wound infusion; Local anesthesia
• ISSN: 1090-0233; 1532-2971
• DOI: 10.1016/j.tvjl.2010.11.008

Thirty-one dogs were randomised to receive intermittent wound infusion of bupivacaine or saline after surgery. Wound pressure sensitivity, pain scores, body temperature, heart rate, respiratory rate, analgesic drugs administered, time to walking and time to eating after surgery were recorded. Plasma bupivacaine concentrations were measured. The relative frequency distributions of the non-interventional and interventional pain scores, but not the relative frequency distributions of palpation pain scores or wound pressure sensitivity, were significantly different between groups following surgery. There was a significant difference between groups in the time to eating and in the amount and timing of analgesic drugs administered. Measured plasma bupivacaine concentrations demonstrated systemic absorption of the drug. Bupivacaine infusion into surgical wounds after surgery may improve post-operative recovery, but no effect on wound tenderness was demonstrated in this study.