Comparative Outcomes of Candida auris Bloodstream Infections: A Multicenter Retrospective Case-Control Study

• Published in: Clinical infectious diseases Vol. 76; no. 3; pp. e1436 - e1443
• Main Authors: Simon, Samuel P, Li, Rosanna, Silver, Michael, Andrade, Justin, Tharian, Biju, Fu, Lung, Villanueva, Diana, Abascal, Daniel Gonzalez, Mayer, Ariel, Truong, James, Figueroa, Nilka, Ghitan, Monica, Chapnick, Edward, Lin, Yu Shia
• Format: Journal Article
• Language: English
• Published: United States 08.02.2023
• Subjects: Antifungal Agents - therapeutic use; Candida; Candida auris; Candidemia; Case-Control Studies; Humans; Microbial Sensitivity Tests; Retrospective Studies; Candida auris; candidemia; micafungin; echinocandin
• ISSN: 1058-4838; 1537-6591
• DOI: 10.1093/cid/ciac735

This study was performed to compare clinical characteristics and outcomes between patients with bloodstream infections (BSIs) caused by Candida auris and those with BSIs caused by other Candida spp. A multicenter retrospective case-control study was performed at 3 hospitals in Brooklyn, New York, between 2016 and 2020. The analysis included patients ≥18 years of age who had a positive blood culture for any Candida spp. and were treated empirically with an echinocandin. The primary outcome was the 30-day mortality rate. Secondary outcomes were 14-day clinical failure, 90-day mortality rate, 60-day microbiologic recurrence, and in-hospital mortality rate. A total of 196 patients were included in the final analysis, including 83 patients with candidemia caused by C. auris. After inverse propensity adjustment, C. auris BSI was not associated with increased 30-day (adjusted odds ratio, 1.014 [95% confidence interval, .563-1.828]); P = .96) or 90-day (0.863 [.478-1.558]; P = .62) mortality rates. A higher risk for microbiologic recurrence within 60 days of completion of antifungal therapy was observed in patients with C. auris candidemia (adjusted odds ratio, 4.461 [95% confidence interval, 1.033-19.263]; P = .045). C. auris BSIs are not associated with a higher mortality risk than BSIs caused by other Candida spp. The rate of microbiologic recurrence was higher in the C. auris group.