Synthesis and Chemico-Pharmaceutical Characteristics of a Somatostatin Analog with Antitumor Activity

An analog of somatostatin with hormonal and antitumor activity was synthesized. An optimum synthesis method was developed, yielding standard pharmaceutical somatostatin analog substance for preclinical and clinical studies. A quality control method was developed for inclusion in the draft manufactur...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 48; no. 3; pp. 159 - 162
Main Authors Shprakh, Z. S., Yartseva, I. V., Ignat’eva, E. V., Smirnova, A. P., Sushinina, L. P., Ustinkina, S. V., Smirnova, L. I., Bud’ko, A. P., Zimakova, N. I.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.06.2014
Springer
Subjects
Amino acids
Medicine
Organic Chemistry
Peptides
Pharmacology/Toxicology
Pharmacy
Pituitary hormones
somatostatin (SST)
antitumor activity
chemico-pharmaceutical analysis
peptide synthesis
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Summary:An analog of somatostatin with hormonal and antitumor activity was synthesized. An optimum synthesis method was developed, yielding standard pharmaceutical somatostatin analog substance for preclinical and clinical studies. A quality control method was developed for inclusion in the draft manufacturer’s pharmacopeia monograph for pharmacological somatostatin analog substance.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1069-8