Myocyte changes in heart failure

Structural remodeling is a major feature of heart failure and typically precedes the development of symptomatic disease. Structural remodeling of the heart reflects changes in myocyte morphology. Disproportional myocyte growth is observed in pathologic concentric hypertrophy (myocyte thickening) and...

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Bibliographic Details
Published inHeart failure clinics Vol. 8; no. 1; p. 1
Main Authors Savinova, Olga V, Gerdes, A Martin
Format Journal Article
LanguageEnglish
Published United States 01.01.2012
Subjects
Animals
Disease Progression
Heart Failure - classification
Heart Failure - pathology
Heart Failure - physiopathology
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Humans
Myocardial Contraction - physiology
Myocytes, Cardiac - pathology
Ventricular Remodeling
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Summary:Structural remodeling is a major feature of heart failure and typically precedes the development of symptomatic disease. Structural remodeling of the heart reflects changes in myocyte morphology. Disproportional myocyte growth is observed in pathologic concentric hypertrophy (myocyte thickening) and in eccentric dilated hypertrophy (myocyte lengthening). Alterations in myocyte shape lead to changes in chamber geometry and wall stress. Human and animal studies indicate that changes in myocyte morphology are reversible. Normalization or reversal of maladaptive cardiomyocyte remodeling should be a therapeutic aim that can prevent deterioration or improve cardiac function in heart failure.
ISSN:1551-7136
DOI:10.1016/j.hfc.2011.08.004