Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance

The human glutathione S-transferase, GSTs, possess both enzymatic and non-enzymatic functions and are involved in many important cellular processes, such as, phase II metabolism, stress response, cell proliferation, apoptosis, oncogenesis, tumor progression and drug resistance. The non-enzymatic fun...

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Bibliographic Details
Published inCurrent opinion in pharmacology Vol. 7; no. 4; pp. 367 - 374
Main Authors Lo, Hui-Wen, Ali-Osman, Francis
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2007
Subjects
Antineoplastic Agents - pharmacology
Drug Delivery Systems
Drug Design
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic
Glutathione Transferase - genetics
Glutathione Transferase - metabolism
Humans
Internal Medicine
Medical Education
Neoplasms - drug therapy
Neoplasms - physiopathology
Pharmacogenetics
Polymorphism, Genetic
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Summary:The human glutathione S-transferase, GSTs, possess both enzymatic and non-enzymatic functions and are involved in many important cellular processes, such as, phase II metabolism, stress response, cell proliferation, apoptosis, oncogenesis, tumor progression and drug resistance. The non-enzymatic functions of GSTs involve their interactions with cellular proteins, such as, JNK, TRAF, ASK, PKC, and TGM2, during which, either the interacting protein partner undergoes functional alteration or the GST protein itself is post-translationally modified and/or functionally altered. The majority of GST genes harbor polymorphisms that influence their transcription and/or function of their encoded proteins. This overview focuses on recent insights into the biology and pharmacogenetics of GSTs as a determinant of cancer drug resistance and response of cancer patients to therapy.
Bibliography:ObjectType-Article-2
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ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2007.06.009