Synthesis of 4,6-Disubstituted 2-Thioxo-1,2-dihydropyridine-3-carbonitriles by the Reaction of Acetylenic Ketones with Cyanothioacetamide

The reaction of acetylenic ketones with cyanothioacetamide in the presence of morpholine yields 4,6-disubstituted 2-thioxo-1,2-dihydropyridine-3-carbonitriles. Structure of the obtained compounds was proved using 2D NMR spectroscopy, as well as transformations into 3-aminothieno[2,3 -b ]pyridine-2-c...

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Published inRussian journal of general chemistry Vol. 89; no. 5; pp. 886 - 895
Main Authors Buryi, D. S., Dotsenko, V. V., Levashov, A. S., Lukina, D. Yu, Strelkov, V. D., Aksenov, N. A., Aksenova, I. V., Netreba, E. E.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.05.2019
Springer Nature
Springer
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Ketones
Morpholine
NMR spectroscopy
Nuclear magnetic resonance spectroscopy
Physical Sciences
Pyridine
Science & Technology
thieno-[2,3
cyanothioacetamide
Bohlmann-Rahtz reaction
Thorpe-Ziegler reaction
acetylenic ketones
pyridines
3-b]pyridines
CHEMISTRY
DERIVATIVES
thieno-
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Summary:The reaction of acetylenic ketones with cyanothioacetamide in the presence of morpholine yields 4,6-disubstituted 2-thioxo-1,2-dihydropyridine-3-carbonitriles. Structure of the obtained compounds was proved using 2D NMR spectroscopy, as well as transformations into 3-aminothieno[2,3 -b ]pyridine-2-carboxamide derivatives.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219050050