Synthesis and Pharmacological Activity of Amino Alcohols of the Indole Series

• Published in: Pharmaceutical chemistry journal Vol. 47; no. 3; pp. 125 - 129
• Main Authors: Suzdalev, K. F., Spasov, A. A., Yakovlev, D. S., Kosolapov, V. A., Kucheryavenko, A. F., Gurova, N. A., Naumenko, L. V., Kuznetsova, V. A., Grechko, O. Yu, Kolobrodova, N. A., Mitina, T. M., Mal’tsev, D. V., Babakova, M. N., Den’kina, S. V.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.06.2013; Springer
• Subjects: Anti-arrhythmia drugs; Antioxidants; Heterocyclic compounds; Medicine; Nitrogen; Organic Chemistry; Pentoxifylline; Pharmacology/Toxicology; Pharmacy; Proteases; The Search for New Drugs; 1-oxiranylmethylindoles; antioxidant; indole; U50,488; quinidine; dibunol; antiarrhythmic; reactive blue 2; κ-opioid activity; antagonist; hemorheological activity; ketanserin; acetylsalicylic acid; ondansetron; 1,2-amino alcohols of the indole series; P2Y; antiaggregant; pentoxifylline; 5-HT
• ISSN: 0091-150X; 1573-9031
• DOI: 10.1007/s11094-013-0909-2

Opening of the oxirane ring in 1-oxiranylmethylindoles yielded new indole derivatives containing 1,2-amino alcohol residues at the nitrogen atom. Compounds were studied in vitro in relation to various types of pharmacological activity typical of this class of compounds, including receptor (5-HT 2 , 5-HT 3 , P2Y 1 -ergic, κ-opioid), antiaggregant, hemorheological, antiarrhythmic, and antioxidant activities.