Integration of neuro-endocrine immune responses in defense of mucosal surfaces

Neuro-endocrine immunology, a field arising from curiosity about the mind-body connection, is evolving rapidly. From intriguing, but seemingly unexplainable observations with human infections and disease, experimental systems have been developed that provide a solid scientific basis for new understa...

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Bibliographic Details
Published inThe American journal of tropical medicine and hygiene Vol. 60; no. 4; pp. 26 - 34
Main Authors BEFUS, A. D, MATHISON, R, DAVISON, J
Format Conference Proceeding Journal Article
LanguageEnglish
Published Lawrence, KS Allen Press 01.04.1999
Subjects
Animals
Biological and medical sciences
Enterocolitis - immunology
General aspects
Granuloma - immunology
Humans
Immune System - immunology
Immunity, Mucosal
Infection pathogenesis
Infectious diseases
Inflammation - immunology
Mast Cells - immunology
Medical sciences
Nervous System - immunology
Neuropeptides - physiology
Neurosecretory Systems - immunology
Schistosomiasis mansoni - immunology
Submandibular Gland - immunology
Sympathetic Nervous System - immunology
Tropical medicine
Infection
Immunology
Immune response
Pathophysiology
Interaction
Mucosa
Parasite
Neuroendocrine regulation
Host
Review
Defense
Surface
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Summary:Neuro-endocrine immunology, a field arising from curiosity about the mind-body connection, is evolving rapidly. From intriguing, but seemingly unexplainable observations with human infections and disease, experimental systems have been developed that provide a solid scientific basis for new understanding. There have been major efforts to understand influences of the nervous system on immune and inflammatory responses, e.g., innervation of the immune system, molecular communication pathways, and complex phenomena such as conditioning of immune responses and mechanisms of host defenses. In turn, the immune system communicates with the neuro-endocrine systems. Imbalances in the neuro-endocrine-immunologic circuitry are relevant in host defenses and in injury and repair. Examples of these themes in neuro-endocrine-immunology arise in several host-parasite models of neurogenic inflammation, immediate hypersensitivity responses, and granuloma formation. The hypothalamic-pituitary-adrenal axis and the cervical sympathetic trunk-submandibular gland axis provide important models to enhance understanding of this poorly known component of the host-parasite relationship.
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ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.1999.60.26