Narrowband diffuse reflectance spectroscopy in the 900–1000 nm wavelength region to quantify water and lipid content of turbid media

We report a narrow wavelength band diffuse reflectance spectroscopy (nb-DRS) method to determine water and fat ratios of scattering media in the 900–1000 nm range. This method was shown to be linearly correlated with absolute water and fat concentrations as tested on a set of turbid emulsion phantom...

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Bibliographic Details
Published inBiomedical optics express Vol. 12; no. 6; pp. 3091 - 3102
Main Authors Lam, Jesse H., Tu, Kelsey J., Kim, Sehwan
Format Journal Article
LanguageEnglish
Published Optical Society of America 01.06.2021
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Summary:We report a narrow wavelength band diffuse reflectance spectroscopy (nb-DRS) method to determine water and fat ratios of scattering media in the 900–1000 nm range. This method was shown to be linearly correlated with absolute water and fat concentrations as tested on a set of turbid emulsion phantoms with a range of water and lipid compositions. Robustness to scattering assumptions was demonstrated and compared against measured scattering by a frequency-domain photon migration system. nb-DRS was also tested on ex-vivo porcine samples and compared against direct tissue water extraction by analytical chemistry methods. We speculate nb-DRS has potential applications in portable devices such as clinical and digital health wearables.
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ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.425451