Comparison of the usefulness of the cardio-ankle vascular index and augmentation index as an index of arteriosclerosis in patients with essential hypertension

• Published in: Hypertension research Vol. 45; no. 3; pp. 455 - 463
• Main Authors: Ishida, Kazuya, Morimoto, Satoshi, Horiuchi, Sayuri, Kimura, Miwa, Ishikawa, Toru, Kimura, Shihori, Yamashita, Kaoru, Takano, Noriyoshi, Seki, Yasufumi, Bokuda, Kanako, Sasaki, Nobukazu, Watanabe, Daisuke, Ichihara, Atsuhiro
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.03.2022
• Subjects: Ankle; Ankle - blood supply; Ankle Brachial Index; Arteriosclerosis; Atherosclerosis; Carotid Intima-Media Thickness; Essential Hypertension; Humans; Hypertension; Medical tests; Peptides; Quality of Life; Vascular Stiffness; Hypertension; Cardio-ankle vascular index; Augmentation index; Atherosclerosis
• ISSN: 0916-9636; 1348-4214
• DOI: 10.1038/s41440-021-00823-x

Arteriosclerosis leads to various serious diseases that substantially reduce the quality of life. When treating hypertension, it is important to evaluate the degree of arteriosclerosis. In recent years, the cardio-ankle vascular index and augmentation index have been frequently used as indicators of arterial wall sclerosis. However, the superiority of either the cardio-ankle vascular index or the augmentation index as an index of arteriosclerosis remains unclear. Therefore, the present study compared the usefulness of these two indices as an index of arteriosclerosis. Associations between the cardio-ankle vascular index or augmentation index and risk factors for arteriosclerosis and other indices of arteriosclerosis in 535 consecutive patients with essential hypertension were evaluated. The cardio-ankle vascular index was significantly correlated with age, hemoglobin A1c, brain natriuretic peptide, and estimated glomerular filtration rate. In contrast, the augmentation index showed significant correlations only with age, brain natriuretic peptide, and estimated glomerular filtration rate. In addition, these correlations with the augmentation index were generally weaker than those with the cardio-ankle vascular index. The cardio-ankle vascular index, but not the augmentation index, was significantly correlated with flow-mediated dilation, an index of vascular endothelial function, and carotid intima-media thickness, an index of carotid atherosclerosis. Similar results were observed in subgroups stratified by sex and age. These data indicate that the cardio-ankle vascular index is more closely associated with risk factors for arteriosclerosis and other indices of arteriosclerosis than the augmentation index, suggesting that the cardio-ankle vascular index may be superior to the augmentation index as an index of arteriosclerosis.