Sequential, One-Pot Access to Arylated Benzoquinones/Naphthoquinones from Phenols/Naphthols

• Published in: European journal of organic chemistry Vol. 2016; no. 13; pp. 2284 - 2289
• Main Authors: Jiang, Jia-Heng, Boominathan, Siva Senthil Kumar, Hu, Wan-Ping, Chen, Chung-Yu, Vandavasi, Jaya Kishore, Lin, Ying-Ting, Wang, Jeh-Jeng
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.05.2016; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Subjects: Chemistry; Chemistry, Organic; Cytotoxicity; Metal-free; Phenols; Physical Sciences; Quinones; Science & Technology; Synthetic methods; Triflic acid; Quinones; Triflic acid; ARYLQUINONES; Metal-free; Cytotoxicity; SYSTEMS; Synthetic methods; C-H FUNCTIONALIZATION; AROMATIC-COMPOUNDS; DERIVATIVES; CONJUGATE ADDITION

A sequential one‐pot approach towards arylated benzoquinones and naphthoquinones is reported. The reaction proceeds through oxidation of phenols/naphthols followed by CH‐arylation with a catalytic amount of triflic acid. Preliminary cytotoxic studies were carried out with five different cell lines a...