Sequential, One-Pot Access to Arylated Benzoquinones/Naphthoquinones from Phenols/Naphthols

A sequential one‐pot approach towards arylated benzoquinones and naphthoquinones is reported. The reaction proceeds through oxidation of phenols/naphthols followed by CH‐arylation with a catalytic amount of triflic acid. Preliminary cytotoxic studies were carried out with five different cell lines a...

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Published inEuropean journal of organic chemistry Vol. 2016; no. 13; pp. 2284 - 2289
Main Authors Jiang, Jia-Heng, Boominathan, Siva Senthil Kumar, Hu, Wan-Ping, Chen, Chung-Yu, Vandavasi, Jaya Kishore, Lin, Ying-Ting, Wang, Jeh-Jeng
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.05.2016
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Chemistry
Chemistry, Organic
Cytotoxicity
Metal-free
Phenols
Physical Sciences
Quinones
Science & Technology
Synthetic methods
Triflic acid
Quinones
Triflic acid
ARYLQUINONES
Metal-free
Cytotoxicity
SYSTEMS
Synthetic methods
C-H FUNCTIONALIZATION
AROMATIC-COMPOUNDS
DERIVATIVES
CONJUGATE ADDITION
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Summary:A sequential one‐pot approach towards arylated benzoquinones and naphthoquinones is reported. The reaction proceeds through oxidation of phenols/naphthols followed by CH‐arylation with a catalytic amount of triflic acid. Preliminary cytotoxic studies were carried out with five different cell lines and some of the compounds show promising activity. This one‐pot approach towards arylated benzoquinones and naphthoquinones proceeds through oxidation of phenols/naphthols followed by CH‐arylation. Preliminary cytotoxic studies for some of the compounds showed promising activity.
Bibliography:ark:/67375/WNG-ZRVC8ZGX-R
istex:74F3B00505F48BF7FD80E5BEE51C1B73E6D9BBFD
ArticleID:EJOC201600119
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201600119