Tc-99m HMPAO brain SPECT compared to CT and EEG after seizures in childhood

Twenty-one children with various seizure disorders were studied using Tc-99m HMPAO brain SPECT, cranial CT, and electroencephalography (EEG). The rates of pathologic findings on SPECT, CT, and EEG were 67%, 38%, and 52%, respectively. SPECT showed congruent, or more extensive, lesions in all eight p...

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Bibliographic Details
Published inClinical nuclear medicine Vol. 20; no. 9; p. 803
Main Authors Alper, E, Koksal, N, Hacimustafaoglu, M, Akbunar, T, Eralp, O
Format Journal Article
LanguageEnglish
Published United States 01.09.1995
Subjects
Brain - diagnostic imaging
Cerebrovascular Circulation
Electroencephalography
Female
Humans
Infant
Male
Organotechnetium Compounds
Oximes
Seizures - diagnosis
Seizures - diagnostic imaging
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
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Summary:Twenty-one children with various seizure disorders were studied using Tc-99m HMPAO brain SPECT, cranial CT, and electroencephalography (EEG). The rates of pathologic findings on SPECT, CT, and EEG were 67%, 38%, and 52%, respectively. SPECT showed congruent, or more extensive, lesions in all eight patient with CT lesions. Six of the 13 children who had normal CT results, had abnormal SPECT study results. In this postictal series, 4 of the 14 abnormalities detected in the first SPECT study that was applied within 24 hours of a seizure, were in the form of hyperperfused areas. Eight of the 14 abnormal first SPECT studies had become normal by the second SPECT. We conclude that, with respect to the depiction of some kind of abnormality, HMPAO brain SPECT is superior to CT and EEG, and considerable changes in brain perfusion are likely to occur over a period of a few weeks.
ISSN:0363-9762
DOI:10.1097/00003072-199509000-00009