Association of miR-4293 rs12220909 polymorphism with cancer risk: A meta-analysis of 8394 subjects

• Published in: Medicine (Baltimore) Vol. 99; no. 32; p. e21364
• Main Authors: Liu, Rongqiang, Fu, Hongyuan, Yu, Yajie, Xu, Qianhui, Fang, Jiangwen, Ge, Qianmin, Shao, Yi
• Format: Journal Article
• Language: English
• Published: United States the Author(s). Published by Wolters Kluwer Health, Inc 07.08.2020; Wolters Kluwer Health
• Subjects: Genetic Predisposition to Disease - genetics; Humans; MicroRNAs - genetics; Neoplasms - genetics; Polymorphism, Single Nucleotide - genetics; Systematic Review and Meta-Analysis
• ISSN: 0025-7974; 1536-5964; 1536-5964
• DOI: 10.1097/MD.0000000000021364

Several studies have investigated miR-4293 rs12220909 polymorphisms and cancer susceptibility and yielded different results. Because of this controversy, we designed a meta-analysis to assess comprehensively the association of the rs12220909 polymorphism with cancer risk. Relevant articles were collected by searching the databases of PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and WanFang. Data on rs12220909 in cancer patients and controls were extracted. Sensitivity analyses and publication bias assessments were performed. Five studies with 3820 cases and 4574 controls were included in our meta-analysis. Pooled analyses showed that the rs12220909 polymorphism was not associated with cancer risk in any genetic model. (C vs G: odds ratio [OR] = 0.89, 95% confidence interval [CI] = 0.74-1.07; GC vs GG: OR = 0.83, 95% CI = 0.67-1.03; CC vs GG: OR = 1.06, 95% CI = 0.82-1.36; CC+GC vs GG: OR = 0.84, 95% CI = 0.69-1.03; CC vs GC+GG: OR = 1.10, 95% CI = 0.85-1.40). Our results indicate that rs12220909 is not associated with cancer risk. Larger, well-designed multicenter studies are needed to further explore the association of miR-4293 rs12220909 polymorphism with cancer risk.