Incidence of Abnormal Plasminogen in Healthy Adults and in Several Diseases in Japanese Population

• Published in: Blood & Vessel Vol. 19; no. 1; pp. 59 - 67
• Main Authors: KAZAMA, Mutsuyoshi, TAHARA, Chieko, MATSUMOTO, Kenji, ZHANG, Qilang, NAITO, Iwao, MATSUDA, Juzo, ABE, Takeshi
• Format: Journal Article
• Language: English
• Published: The Japanese Society on Thrombosis and Hemostasis 1988
• Subjects: Abnormal plasminogen; AC/AG ratio; Immunostaining; Incidence; Zymogram
• ISSN: 0386-9717; 1884-2372
• DOI: 10.2491/jjsth1970.19.59

We examined 1, 479 pilot plasmas of blood donors, 171 cases of cerebral infarction and 37 cases of SLE for their activities and antigen levels of plasminogen. M±SD of the activity of donor blood was 83.5±17.3% and that of antigen level was 111±19μg/ml, i. e. 86.7±14.8%. The mean activity-antigen ratio (AC/AG) was 0.96±0.15. It was found that 82 cases had plasminogen activity lower than 60%, and finally 50 cases (3.8%) were diagnosed as abnormal plasminogen as they had AC/AG less than 0.66. Zymogram and immunostaining after IEF of these specimens revealed that the phenotype of one case was homozygote (type 1′-1′) and those of 49 were heterozygotes (type 1-1′). The incidences of the abnormality were not statistically different between three separate prefectures. The incidence of this abnormality was 4.7% (8/171) in cases of cerebral infarction and that in SLE was 10.8% (4/37). It was concluded that abnormal plasminogen is regarded not as the primary causative factor but the predisposing one of thromboembolism. High risk of thrombosis develops when abnormal plasminogen is complicated with any form of vascular damages, such as trauma, operation and inflammation.