Genetic association between bone mineral density and the fracture of distal radius: A case-control study

• Published in: Medicine (Baltimore) Vol. 100; no. 36; p. e27116
• Main Authors: Li, Hongliang, Fu, Mingyun, Gao, Junqing, Fu, Jile, Li, Tuming, Niu, Guoqing
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 10.09.2021
• Subjects: Absorptiometry, Photon; Asian People; Bone Diseases, Metabolic - complications; Case-Control Studies; China - epidemiology; Female; Genetic Predisposition to Disease; Humans; Middle Aged; Observational Study; Osteoporotic Fractures - epidemiology; Osteoporotic Fractures - etiology; Osteoporotic Fractures - genetics; Radius Fractures - epidemiology; Radius Fractures - etiology; Radius Fractures - genetics; Retrospective Studies; Risk Factors; China
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000027116

Low bone mineral density (BMD) was significantly related to the fracture of distal radius. Serum brain-derived neurotrophic factor (BDNF) level was closely related to BMD in spine and osteoporotic fractures. In this study, we aimed to explore the association of BDNF polymorphisms (rs6265 and rs7124442) with BMD and the fracture of distal radius.This retrospective study included 152 patients with distal radius fractures and 148 healthy controls. BDNF polymorphisms were detected via TaqMan allelic discrimination assay. BMD was evaluated through X-ray. Difference in features between cases and controls were compared adopting Chi-square test or t test. The associations of BDNF polymorphisms with fracture risk of distal radius and BMD were assessed employing χ2 test and expressed by odd ratios (ORs) with 95% confidence intervals (95% CIs).BMD was significantly decreased in patients with the fracture of distal radius than in healthy controls. The polymorphism rs6265 significantly increased the risk of distal radius fracture (adjustment: GA: OR = 1.724, 95%CI = 1.003 -2.951, P = .049; GG: OR = 2.415, 95%CI = 1.0219 -3.674, P = .005). Moreover, rs6265 genotypes GA (OR = 4.326, 95%CI = 1.725 -11.896, P = .003) and GG (OR = 13.285, 95%CI = 3.659 -51.072, P = .001) significantly increased BMD reduction. However, BDNF polymorphism rs7124442 had no obvious correlation with BMD or fracture risk.BMD was associated with BDNF rs6265 polymorphism. BDNF polymorphism rs6265 could elevate the risk of osteoporosis and distal radius fracture.