Reference intervals of anti‐Müllerian hormone in Korean women

• Published in: Journal of clinical laboratory analysis Vol. 36; no. 9; pp. e24525 - n/a
• Main Authors: Choi, Rihwa, Lee, Sang Gon, Lee, Eun Hee
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.09.2022; John Wiley and Sons Inc
• Subjects: Age; Age groups; anti‐Müllerian hormone; Automation; Brief Report; Fertility; health checkup; Health promotion; Korea; Medical laboratories; Menstruation; ovarian reserve; Ovaries; Polycystic ovary syndrome; Population; Population studies; reference interval; Reproductive system; Software; Statistical analysis; Womens health
• ISSN: 0887-8013; 1098-2825; 1098-2825
• DOI: 10.1002/jcla.24525

Background Limited data are available with reference intervals of serum anti‐Müllerian hormone (AMH) level in Korean women. Methods We retrospectively reviewed serum AMH test results performed with automated electrochemiluminescence immunoassay in Korean women who visited health promotion centers between January 2019 and December 2020. Serum AMH results by age group were compared with previously reported reference intervals. Results During the 2‐year study period, a total of 1953 AMH test results from Korean women (age 20–49 years) undergoing general health checkups were obtained. Serum AMH level differed significantly by age group. Peak AMH level was observed at age 25–29 years and decreased to undetectable for subjects older than 44 years. The 2.5th, 5th, and 10th percentile values of the present study were comparable with previously assessed lower limits of reference intervals. The upper limit of the reference interval defined as the 97.5th percentile value in women younger than 35 years was higher than that of Western populations. The 90th percentile value of the present study population was similar to the 95th or 97.5th percentile value of reference intervals for Western populations of women younger than 35 years. Conclusion Understanding patient populations and differences in reference intervals by age group and measurement method can help guide clinical decisions and clinical laboratory analysis.